Rejuran

Rejuran (Polynucleotide Therapy):

Mechanism & Clinical Benefits

Rejuran is an injectable skin treatment composed of polynucleotides (PN), biocompatible DNA fragments derived from salmon. These molecules act as tissue repair stimulators, targeting skin regeneration at a cellular level.

🧬 Mechanism of action:

Polynucleotides:• Stimulate fibroblast activity → increased collagen and elastin synthesis• Promote angiogenesis → improved microcirculation• Enhance extracellular matrix (ECM) repair• Provide anti-inflammatory effects via free radical scavenging• Improve dermal hydration through water-binding properties

📊 Clinical effects:• Improved skin elasticity and thickness• Reduction in fine lines and superficial wrinkles• Enhanced skin texture and pore refinement• Adjunctive benefit in acne scarring and post-inflammatory damage• Restoration of impaired skin barrier

💉 Treatment protocol:Typically administered via intradermal microinjections (mesotherapy technique)• Course: 3–4 sessions• Interval: 2–4 weeks• Maintenance: every 6–12 months depending on indication.

Considerations:• Mild downtime (erythema, papules, bruising)• Gradual onset of results over weeks• Best outcomes when combined with other modalities (e.g. laser, microneedling)